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This article analyses the institutionalization of global health public private partnerships since the 1990s. It shows that the loose and imprecise formulation of a norm of cooperation with businesses, in the context of the reform of the UN system and according to a top-down process, and its subsequent clarification through the Global Compact and the Millenium Development Goals, triggers a phase of diffusion organized around the notion of ‘partnership’ which remains sufficiently vague for it to be the object of various appropriations. Among these, a specific form can be distinguished that can be defined in a pertinent manner: global health public-private partnerships.