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This paper is a brief introduction to and interpretation of the work of Joe Orton, an English playwright of the 1960s who achieved notoriety through the violent and obscene content of his plays, his scandalous homosexual lifestyle and brutal death at the hands of his lover. Orton’s work is presented as a dramatic exemplification of distinctive themes pertaining to a radically materialistic strain in philosophy anticipated in Machiavelli and Spinoza but finding its fullest expression in Deleuze’s thought: the radical immanence of the political, the critique of self-identity and clinical concepts of madness, and the anarchic and impersonal force of sexual desire. Orton achieves this aim through comic experimentation with language and a radicalisation of farce that serve to produce a laughter that is both destructive and affirmative: destructive of the boundaries artificially erected by reason (including the boundary between the artificial and the natural), and affirmative of this process of destruction and the pre-subjective desire through which it is accomplished.