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To mark twenty years of the REIN (French Renal Epidemiology and Information Network), a summary report on the contributions of the French national end-stage kidney disease (ESKD) registry was produced. On its information system, a number of key takeaways were identified. The REIN information system supports the registry throughout the life cycle of the data. Two collection tools, one for dialysis and the other for transplantation, are accessible via a secure WEB site. Several data quality control tools have been added. Finally, the REIN information system includes several reporting tools, including a geographic information system.© 2022 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.