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Microscopic polyangiitis is a type of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis affecting the small blood vessels. We report a case of microscopic polyangiitis in a 31-year-old male patient with renal, skin, and neurological manifestations, which was probably triggered by a selective serotonin reuptake inhibitor. On induction therapy with corticosteroids and cyclophosphamide, his renal recovery was complete, and his neurological recovery was slow but satisfactory.