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The primary function of religion is a spirituality that allows humans to think the world and to think themselves within the universe. By claiming to indicate the path to “salvation”, some teachings are likely to be demanding exclusivity or to be ideologised to the point of fuelling or justifying violence. The omnipresence of religion in a world ruled lead by reason and the necessity to promote transcultural clinical studies that respect anyone’s singularity demand a reflection on religion as a cultural and social phenomenon. The discussion on two clinical cases, one related to Islam, the second to Evangelism, will allow us to explain why it is important to not close the clinical space to religious representations if it is necessary to act towards a “return to self” to be able to “move toward the Other”, and if it is necessary to deconstruct the beliefs that limit the integration of the subjects or expose them to a risk of captation by a life-denying ideology.