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On October 27, 2016 a symposium entitled “Interdisciplinarity: Discourse and reality” was held at the Université libre de Bruxelles. It had been preceded by a survey of French-speaking researchers on their actual practice in this regard. The survey yielded 104 responses that have been thoroughly reviewed and the results discussed regarding the state of the art related to the surveys on interdisciplinarity. In addition, international speakers shared their experiences in different areas during the day. One of the lessons from these discussions is that there is currently a rich and diversified practice which contrasts somewhat with the picture of difficulty often associated with interdisciplinarity. Our paper presents these results and adds analyses and proposals stemming from the discussions. This symposium was organized within the framework of the “Séminaires Prigogine – Penser la science”.