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This article presents the first conclusions on research whose aim is to study the developmental process of brothers and sisters of autistic children and to analyze the difficulties involved. Our basis is the psychoanalytical hypothesis that a subject constructs for himself by means of the instinctual relationship established with the Other. When this instinctual relationship with the Other is not set into place, we observe a difficulty in the constitution of the subject. Autism is the consequence of the non-installation of this connection due to several factors. We suppose that among the siblings of an autistic child, there will be obstacles to the installation of this link. To verify this hypothesis, we use clinical indicators of risk for infantile development (IRDI) and the signs of the Research program on Autism (PREAUT) in order to analyze six clinical cases of brothers and sisters of autistic children.