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The psychosocial impact of lockdown or quarantine measures have been documented in pandemics over the last decades. However, none of these pandemics had severely impacted Western Europe. Covid-19, as global pandemic has unprecedently impacted the public. In France, lockdown and lockdown-exit experiences and attitudes have been documented. Preliminary data highlights vulnerability factors and increased distress and/or symptoms in vulnerable groups. The authors emphasise public mental health challenges and the need for prevention and support strategies to be developed.