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Faced with an increase in the practice of chemsex, the Infectious and Tropical Diseases Department at Hôpital Saint-Louis (AP-HP) took the necessary steps to be able to offer a specialized multidisciplinary care pathway in 2019. Nurses were trained in risk and harm reduction (RdRD) related to chemsex, and awareness-raising was carried out with the entire team to prepare them to treat these users. The department’s doctors identify relevant patients and refer those who are willing to RdRD consultations. As part of these consultations, nurses conduct RdRD interviews with chemsex patients wishing to change or take stock of their consumption practices. At each consultation, the nurse specialist and the user set a RdRD objective, and a personalized action plan is drawn up, helping in particular to manage cravings. The means of action are reassessed at each session, and new objectives are set. Patients are referred to the referring doctor, psychiatrist, psychologist, or sexologist in the event of comorbidity or other problems. Between September 2019 and September 2023, 264 users attended chemsex consultations and the nurses carried out 1,115 RdRD consultations. A survey conducted in 2021 demonstrated the value of this cross-disciplinary sexual health care pathway available in a single location, facilitating care for chemsex patients.