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How, and to what extent, is hospital clinicians’ professional experience in terms of diagnosing incurable diseases transformed by a biomedical technology such as Routine Neonatal Screening (NS)? Drawing on the results of a questionnaire addressed to French “Centres de Ressources et de Compétences de la mucoviscidose (cystic fibrosis)”, and on interviews with medical teams, this article seeks to highlight new transversal, flexible and multi-professional practices that face rigid and compartmentalised hospital structures. Such tensions are exacerbated by the fact that doctors are expected to legitimise a new clinical approach by co-managing biographies of affected children – which alienates them from their health care vocation. Moreover, although Routine NS bears potential scientific and technological progress in terms of medicine and biology, it also leads into a largely unknown territory and plays a role in the emergence of an ominous figure : “the healthy yet suspect person”. Finally, this unprecedented form of professionalism forebodes a reconfiguration of the professional experience of doctors, which is increasingly affected by medical technologies.