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The diagnosis of a social cognition disorder in adults is often a complex clinical process, even for simple facial emotion recognition. This appears to be related to the frequent cognitive comorbidities present in patients with social cognition disorders and the high level of difficulty of most social cognition tests. When assessing facial emotion recognition, the neuropsychologist has to consider many factors in addition to the score of correct responses by emotion. Using our work as a starting point, we will focus on the factors to be controlled for when assessing these abilities and give recommendations for the clinical management of these disorders. Three themes will be addressed: the perception of facial emotions (recognition, discrimination, judgment of expressive intensity); moral and conventional judgments and the notion of social dangerousness; and the understanding of humor. This last theme is more of an experimental approach but should be transposed to clinical practice in the short term. We thus present the material from one of our humor comprehension tasks involving verbal and visual input. Our ongoing work on the scoring of happy facial emotions will be discussed. Regarding humor, two studies produced by our clinical team indicated that the model of incongruity detection followed by incongruity resolution may be compatible with multiple sclerosis patient performance outcomes. These studies also suggest that about 60% of these patients may be impaired in humor comprehension (30% as a primary impairment and 30% as a secondary impairment), even for very simple medical interactions.