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The purpose of this study was to validate the French version of the Copenhagen Psychosocial Questionnaire (COPSOQ), which is used to assess psychosocial risk factors at work. The current French version comprises 46 items grouped in 24 scales and referring to 6 dimensions. The questionnaire was administered to 3,166 employees of a large French company based in 10 cities in the Paris region and French provinces. The psychometric analyses (internal consistency analysis, exploratory and confirmatory factor analysis, and concurrent validity analysis) were satisfactory and demonstrated the validity of the French version of the COPSOQ. Large amounts of data are currently being collected with a goal of making comparisons between occupations and between different types of companies.