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Education Santé Territoire (EST) is a health education programme for children and adolescents. It was developed on the basis of the international literature and the results of interventional studies conducted in France. It is based on local resources and develops a territorial approach centered on the school as the reference site of the “perceived territory” of children and adolescents. It therefore comprises a local environment approach (school and college) and a territorial approach, as it is centered on participation and is designed to mobilize local stakeholders involved in the education of young people. It concerns educational activities (in the schoolroom, in the institution, in the context of extracurricular activities, in leisure centres, in sports clubs); the school-community relationship; the quality of life of children and adolescents. The available results show major changes in practices and a wide range of modalities of participation. Factors that determine participation are essentially related to individual determinants (adhesion to the underlying values of the programme, compatibility of representations, perception of the relevance of the content) and contextual factors (numbers, school environment, social environment). Training and the history of involvement in the programme appear to be key elements determining participation.