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Reducing social inequalities in health (SIH) is a key priority for the Provence Alpes Côte d’Azur Regional Health Agency (Paca ARS). The actions and objectives defined in the regional health project were divided into a two-way table (determinants/policies by target population) to verify the consistency and extent of such measures. Sustaining actions of the ARS, alone or in partnership on the determinants of SIH and their effects, target three distinct levels of intervention: in the scope of its own jurisdiction, as a resource for other actors, including support of action research and finally in the context of partnership approaches. It has developed fine measurement and monitoring tools and has supported the development of a continuing education e-learning programme developed with partners in Paca and Quebec.However, further efforts are needed to develop actions on fundamental determinants, including environmental determinants and more effective implementation of this policy. The objectives of certain territorial health programmes designed to make local primary care structures responsible for the population concerned are very promising.