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A promising approach to improve the population’s health and the quality of care and services provided by the health system consists of patient engagement at all levels of the health system together with training of health professionals. Since 2010, a new rational model based on the partnership between patients and healthcare professionals has been developed at the University of Montreal’s Faculty of Medicine. This patient partnership model is based on the recognition of the patient’s experiential knowledge gained from living with a disease, which is complementary to the healthcare professional’s scientific knowledge.This partnership is part of a continuum of patient engagement and can be applied in healthcare, professional training, education and research settings.This article describes the theoretical basis for patient partnerships and how this new model can be implemented in clinical, organizational and systemic levels, as well as the success factors in both patients and healthcare professionals.The Montreal Model provides relevant outlooks for chronic disease management by making patients essential partners in all decisions affecting them and by treating them as experts in the organisation of care. This model should have a significant impact on the population’s health by improving physical, psychological health, as well as the patient’s well-being.As part of this new framework, several research programs are currently underway to evaluate the impact of this model.