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Objective: Disparity in healthcare is widening in France. From the doctors’ perspectives, their relationship with patients in a precarious economic situation raises a number of specific difficulties. The objective of this qualitative study of people in a precarious economic position, was to identify the specific challenges and aspects that can facilitate patient-doctor relationships. Method: This qualitative study was based on a series of individual, semi-structured interviews between GPs and patients over the age of 18 years with a regular GP, and who were financially vulnerable (recipients of state benefits), and/or covered by universal complementary health care insurance, and/or who frequently attended charitable organisations for free food and clothes. Results: A total of 19 people were interviewed. The participants highlighted the expected human dimension : respect, charisma and open-mindedness. A high quality of receptiveness and communication also facilitated the relationship. On the other hand, lack of availability, an authoritative tone and intrusion hindered the relationship. The patients did not appear to have any additional demands related to their economic vulnerability. Conclusion: In conversation with their GPs, the patients did not define themselves by their unstable financial position. The patients’ experience and expectations in relation to interactions with their doctors appeared to be similar to those of the general population.