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Introduction: The longevity of Mutual Health Organization (MHOs) in Cameroon is not guarantee, and it tends to fail after a very short period of functioning. Very little studies talks about the performance of MHOs. Therefore, we will like to measure the financial, economic and mutualist satisfactory performance indicators in two community-based mutual health organizations. That is the Mutual health organization of Douala V (Musocom) and Yaoundé I (Mucamaadd). Methodology: It is a descriptive and analytical study in which sampling was conducted using a non-probability method using a self-administered questionnaire and evaluation grid. Results: It revealed an overall satisfaction of 69%; an availability rate of management tools and activities of 85.5%; a solvency ratio of 34.2%; an expense coverage ratio of 37.4%; an equilibrium ratio of 50.9%; an operating expense ratio of 76% and a loss ratio of 133%. There is a significant association between beneficiary satisfaction and the fact of belonging to a household or small medium size enterprise, enrolling in groups of 6-11 people or <gt; 22 people, being from the private sector or retired and having a salary > 100.000 frs (OR> 1 and P-Value < 0.05). Discussion: The measure of Mutual health organization performance permitted to bring out difficulties, gaps in line with their professionalism, organization and technicality. The findings present a more significant measure of performance in Mucamaadd than in Musocom due to its constant ability in research of amelioration in rendering services.