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In Guadeloupe (French West Indies), the ethnic, social, cultural and religious pluralism makes it difficult, in the French hospitals, to take care of people living with HIV/Aids. Haitian people may suffer from stigmatization and discrimination, because of their ancient accusation in the regional HIV epidemic’s spread. The paper focuses on two types of care. The first one produces inequalities while building a cultural and therapeutic otherness process, based on stereotypes opposed to the ethics of care. The second one tries to put the patient in the heart of the care process, without being focused on one’s culture, and aims at improving social conditions of being and decreasing inequalities. In both cases, hospital’s staff work reveals the difficulty to build a collegial process of care, due to the hospital organization’s limits. It also highlights the necessity to question the hospital’s staff values.