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Based on a clinical study, the authors propose a reflection on certain unconscious subjective issues that accompany the prescription and consumption of psychotropic drugs. The general hypothesis argues that, despite the technical-rational nature of prescription, the question of an otherness “responsible” for the patient’s suffering remains open. Two case studies reveal how experiences of psychical suffering and consumption of psychotropic drugs support an emplotment that relies on other members of the family, as well as on the medical organization (physicians). The experience of consuming psychotropic drugs can then be addressed from the point of view of the unconscious links it maintains with the representations of narcissistic filiation (familial myth, phantasies of transmission, etc.). Both studies also highlight how unconscious conflicts (with the ambivalence they entail) subtend this emplotment, and thus the subjective relation with the consumption and prescription of psychotropic drugs.