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Our aim is to analyze the concept of omnipotence of magic thought in the Renaissance, and in particular with Marsilio Ficino, Giovanni Pico della Mirandola, Tommaso Campanella, and Giordano Bruno. The humanist, thanks to magic, tries to take God’s place; he thinks that his science will allow him to change things and his own fate. Humanist magicians, with their imagination and their intuition, contributed to the birth of modern science. Science ended up taking the place not only of magic thought, but of God himself: in the attempt to fight determinism, science became what determines the subject and their story. Thus, we went from the omnipotence of magic thought to the omnipotence of science. What is the position of psychoanalysis toward these two disciplines?