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The choice to study Amphiaraeus and Asclepius arises primarily from the desire to honor the memory of Pierre Sineux, who, during his entire career, paid great attention to them. He was able to find out the analogies and differences which exist in terms of cult practices and the place occupied by the rite of incubation. I would like here to develop his reflections by approaching, from a comparative perspective, the double identity, heroic and divine, of Amphiaraeus and Asclepius of the Archaic and Classical periods. The unfolding mythical questions of both figures and the implementation and spreading of both cults will be addressed successively, in order to highlight the similarities and specificities of each and to show in which context their updating took place on every occasion.