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The authors describe a set of clinical signs that appear in young children who are exposed to screens of all kinds from an early age. They propose grouping them together under a syndrome called “early and excessive exposure to screens” (EEES). This set of signs includes attention disorders, language delay, and difficulty acquiring fine motor skills, along with displaying an increasingly exclusive interest in screens, relational disorders that manifest in the form of aggressive behavior, and psychomotor instability. With an onset at eight/ten months in children with the highest exposure, this syndrome seems to develop gradually during the second year of life. A main feature of the syndrome is its regression, or even disappearance, if overexposure to screens is quickly ended. However, regression may be only partial if overexposure continues after three or four years of age. The authors propose some psychopathological and developmental understandings of the syndrome, considering screens, particularly small portable screens left in the hands of small children over a long period of time, as real neurodevelopmental disruptors.