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This article looks at the process of territorializing and presenting epidemiological data on a cross-border scale. After identifying the discourses that legitimize the field of cross-border epidemiology, we study a corpus of nine cross-border epidemiological surveillance media devices. Discursive and semio-pragmatic analysis is complemented by interviews. The results highlight the challenges of cross-border sharing of epidemiological data, underscore the proliferation of device names, identify a semiotic organizing principle, and shed light on the underlying logics of the players involved. In conclusion, we take an in-depth look at two issues: informational imbalance and the interaction of specialized skills.