TY - BOOK AU - Wimmer,Jordan AU - Sattler,Laurent AU - Herb,Agathe AU - Pontvianne,Mary AU - Boudier,Éric AU - Hengen,Maryse AU - Thuet,Vincent AU - Feugeas,Olivier AU - Desprez,Dominique TI - Placenta percreta management in a patient with severe congenital hypofibrinogenemia PY - 2023///. N1 - 27 N2 - The obstetrical follow-up of patients with severe hypofibrinogenemia requires a multidisciplinary collaboration because of potential maternal–fetal complications (recurrent miscarriages, intrauterine fetal demise, post-partum hemorrhage, thrombosis). We report the obstetrical management of a multiparous patient with severe congenital hypofibrinogenemia associated with a platelet disorder (abnormal phospholipid externalization). A therapeutic strategy based on a biweekly administration of fibrinogen concentrates combined with enoxaparin and aspirin allowed the maintenance of pregnancy. But this pregnancy became complicated by a placenta percreta requiring a salvage hysterectomy with an appropriate hemorrhage prophylaxis UR - https://shs.cairn.info/journal-annales-de-biologie-clinique-2023-2-page-210?lang=en ER -