TY  - BOOK
AU  - Nekoua,Magloire Pandoua
AU  -  Mercier,Ambroise
AU  -  Vergez,Inès
AU  -  Morvan,Corentin
AU  -  Mbani,Chaldam Jespere
AU  -  Sane,Famara
AU  -  Lobert,Delphine
AU  -  Engelmann,Ilka
AU  -  Romond,Marie-Bénédicte
AU  -  Alidjinou,Enagnon Kazali
AU  -  Hober,Didier
TI  - Coxsackievirus B infection and pathogenesis of type 1 diabetes
PY  - 2022///.
							
N1  - 23
N2  - Epidemiological and experimental studies suggest that enteroviruses (EVs), particularly coxsackieviruses B (CVBs), are likely to trigger or accelerate the onset of islet autoimmunity and the development of type 1 diabetes (T1D) in genetically susceptible individuals. Several mutually non-exclusive mechanisms have been proposed to explain the involvement of CVBs in the pathogenesis of T1D. CVBs can infect and persist in the intestine, thymic cells, monocytes/macrophages, ductal cells, and pancreatic β-cells, leading to structural or functional alterations of these cells. A chronic inflammatory response and disruption of tolerance toward β-cells due to CVB infections encourage the recruitment and activation of pre-existing autoreactive T-cells and the destruction of β-cells. Vaccines and therapeutic strategies to control EV infections have been developed and open up possibilities for the prevention or treatment of T1D
UR  - https://shs.cairn.info/journal-virologie-2022-6-page-415?lang=en
ER  -