TY  - BOOK
AU  - An,Min Kyun
AU  -  Yoon,Ji Ha
AU  -  Park,Eun Joo
AU  -  Park,Hye Rim
AU  -  Kim,Kwang Joong
AU  -  Kim,Kwang Ho
TI  - Differential histopathological and immunohistochemical findings between palmar psoriasis and chronic hand eczema
PY  - 2020///.
							
N1  - 4
N2  - Background: The differential diagnosis between palmar psoriasis (PP), chronic hand dermatitis (CHE), and hyperkeratotic hand dermatitis (HHD) is challenging. Objectives: We sought to distinguish the histopathological and immunohistochemical characteristics between PP, CHD, and HHD. Materials & Methods: Hands, clinically diagnosed with PP, CHD, or HHD, were further evaluated using skin biopsy sections based on haematoxylin and eosin staining and immunohistochemical analysis for β-defensin 2 and interleukin-36γ. Results: Confluent parakeratosis, absent granular layer, and psoriasiform epidermal hyperplasia were more common in PP and HHD relative to CHE. The level of β-defensin 2 expression in the stratum corneum and interleukin-36γ in the stratum granulosum was higher in PP and HHD relative to CHD. Conclusion: Considering the similarities of histopathological and immunohistochemical findings, HHD may be an inflammatory disorder with a pathogenesis similar to that of PP, rather than CHD
UR  - https://shs.cairn.info/revue-european-journal-of-dermatology-2020-6-page-710?lang=en&redirect-ssocas=7080
ER  -