TY  - BOOK
AU  - Neubauer,Christine
AU  -  Kragl,Martin
AU  -  Braun,Theodor
AU  -  Filipek,Przemyslaw
AU  -  Bonyadi Rad,Ehsan
AU  -  Grander,Julia
AU  -  Mähler,Nicole
AU  -  Moritz,Kathrin
AU  -  Hoch,Stefan
AU  -  Ziegler,Ramona
AU  -  Andreev,Stanislav
AU  -  Steindl,Hubert
AU  -  Jakschitz,Thomas
AU  -  Koeberle,Andreas
AU  -  Bonn,Günther
AU  -  Soeberdt,Michael
AU  -  Abels,Christoph
TI  - An oil-in-water emulsion containing a combination of ginger extract and synthetic cannabidiol with potent in vitro anti-inflammatory effects alleviates symptoms of atopic dermatitis in a clinical trial
PY  - 2024///.
							
N1  - 7
N2  - BackgroundAtopic dermatitis (AD) is a highly prevalent chronic skin disease. Anti-inflammatory and antipruritic emollients (emollients plus) with excellent cosmetic properties may alleviate AD-related symptoms and reduce the number of exacerbations.ObjectivesTo screen for herbal extracts with potent anti-inflammatory and antioxidative potential in human skin cell cultures. Ginger extract and synthetic cannabidiol (CBD) were identified and combined in the cosmetic product BNO 3731, which was evaluated in a randomized clinical trial.Materials & MethodsPreclinical: anti-inflammatory effects of ginger extract, synthetic CBD and a combination thereof were evaluated in human skin cell cultures by analysing nuclear factor κB activation, release of inflammatory cytokines and endocannabinoid production. Clinical: BNO 3731 was studied in a clinical trial comprising 44 AD patients (adults and children) and compared to a benchmark product over a treatment duration of five days. Symptom severity was evaluated by objective and subjective dermatological assessments as well as physiological skin parameters. Itch intensity was assessed using a numerical rating scale (NRS-11).ResultsPreclinical: Ginger extract and synthetic CBD exhibited potent anti-inflammatory and antioxidative effects in vitro which were associated with elevated concentrations of the endocannabinoid, anandamide. Clinical: BNO 3731 significantly alleviated symptoms of AD and improved physiological skin parameters. Itch intensity decreased significantly by 55%, and in 75% of subjects, itch improved ≥2 points on the NRS-11 scale. No adverse events were reported.ConclusionBNO 3731, containing a unique synergistic combination of ginger extract and synthetic CBD, is an effective and safe treatment option for dry and eczema-prone skin, providing rapid and substantial relief of pruritus
UR  - https://shs.cairn.info/revue-european-journal-of-dermatology-2024-4-page-416?lang=en&redirect-ssocas=7080
ER  -