TY  - BOOK
AU  - Eckardt,Julia
AU  -  Behrens,Victoria
AU  -  Kofler,Katrin
AU  -  Forchhammer,Stephan
AU  -  Häfner,Hans-Martin
AU  -  Kofler,Lukas
TI  - The impact of haematoxylin-eosin staining and immunohistochemistry of lentigo maligna and lentigo maligna melanoma margins on local recurrence
PY  - 2022///.
							
N1  - 68
N2  - BackgroundLocal recurrence of lentigo maligna melanoma (LMM) and lentigo maligna (LM) continue to be challenging following surgical treatment and aftercare.ObjectivesTo investigate haematoxylin-eosin staining and immunohistochemistry of the tumour margins of LM and LMM and evaluate the impact of these data on local recurrence.Materials & MethodsIn total, 489 tumours were included in this retrospective single-centre study, among them 199 (40.7%) LMs and 290 (59.3%) LMMs. All tumours were excised using micrographiccontrolled surgery. Additional immunohistochemistry staining of the tumour margins was performed in 35 specimens (7.2%).ResultsBased on haematoxylin-eosin staining alone, 82/454 tumours (18.1%) were shown to develop local recurrence compared to 3/35 tumours (8.6%) when additional immunohistochemistry was performed.ConclusionFollowing micrographic-controlled surgery, the additional use of immunohistochemistry of tumour margins of LM/LMM reduced the risk of local recurrence, although this was not statistically significant
UR  - https://shs.cairn.info/revue-european-journal-of-dermatology-2022-6-page-750?lang=en&redirect-ssocas=7080
ER  -