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BackgroundLaser intervention is increasingly recognized as an effective approach to preventing scars, however, as lasers of different wavelengths reach different target tissues, an appropriate combination of laser treatment is required.ObjectivesTo evaluate the efficacy of combining erbium: yttrium aluminium garnet (Er:YAG) 2,940-nm laser and fractional carbon dioxide (CO2) 10,600-nm laser for the treatment of facial scarring.Materials & MethodsMedical records of 39 patients with facial scars were retrospectively reviewed. Treatments initiated within six months post-injury were defined as “early-intervention”, whereas those initiated >six months post-injury were defined as “delayed-intervention”. Patients’ scores on the Vancouver Scar Scale (VSS) and Visual Analogue Scale (VAS) were collected and compared between different timepoints using the paired t-test. Improvement in pigmentation, height, vascularity and pliability was analysed between baseline and after final treatment.ResultsBetween March 2020 and March 2022, 39 patients underwent dual-laser therapy at our laser clinic. The average number of treatments was 4.69 1.54; 18 patients in the early-intervention and 21 patients in the delayedintervention group. Facial scars significantly improved after the first treatment in the delayed-intervention group (p p p = 0.083), however, improvement in height and flexibility was prominent (p p ConclusionThe combination of Er:YAG and fractional CO2 laser is a safe and effective therapeutic modality for facial scarring.