70

BackgroundCicatrylTM cream, a topical medical device, is indicated for the treatment of superficial wounds and small skin injuries.ObjectivesTo assess the efficacy and tolerability of CicatrylTM cream by measuring the recovery of the skin barrier after inducing wounds.Materials & MethodsA suction blister of about 6-mm diameter was induced on the inner side of each forearm of 44 healthy subjects. Using a process of randomisation, CicatrylTM cream was then applied to one wound for a maximum duration of 14 days, while the other wound was left untreated. The primary objective was to evaluate the effect of the test product on wound healing at Day 6, by comparing treated versus untreated wound areas measured by macrophotography. Secondary objectives were to evaluate healing, cutaneous barrier restoration and subjective efficacy of the cream as well as tolerability.ResultsThe mean wound area (± SD) at Day 6 was significantly smaller for treated wounds compared with untreated wounds (1.76±4.71 vs 15.76±7.61 mm2; p 2/day; p ConclusionCicatrylTM cream improves wound healing, especially within the first six days, if applied in accordance with the manufacturer’s instructions.