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Given that the monetary and human costs arising from mental health problems are increasing in most industrialized societies, organizations need to pay attention to their employees’ well-being and its determining factors. This study innovates by investigating whether the links between life-domain interactions (either conflict or enrichment) and well-being (either subjective or psychological) are different for men and women based upon conservation of resources (COR) theory (Hobfoll, 1989, 2002) and the work-home resource model (ten Brummelhuis & Bakker, 2012). Survey responses provided by 798 managers brought some key results. First, although men express a significantly higher average level of personal life → work-life (PL→WL) conflict than women, men’s and women’s perceived life-domain conflicts (either WL→PL or PL→WL) have a statistically similar negative effect on their well-being (either subjective or psychological). Second, although men and women express a similar average level of life-domain enrichments (either PL→WL or WL→PL), men’s perceptions regarding their life-domain enrichments (either WL→PL or PL→ WL) are significantly more positively related to their psychological and subjective well-being. Finally, for both men and women, perceived life-domain enrichments (WL→PL and PL→WL) account for well-being (either subjective or psychological) over and above the influence of the perceived life-domain conflicts (WL→PL and PL→WL).