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This paper discusses the opportunity that hospitalization can represent as a way to think of depression in terms of the psychic metabolization of a significant subjective experience, or its feature. This paper presents the main modalities through which this approach is organized for hospitalized unipolar patients in a phase of depression. It comprises 12 sessions (three per week). The psychotherapist’s intervention is organized around 4 basic themes: the conflict revealed in the crisis surrounding hospitalization, personality structure, briefness of psychotherapy, and the psychopathology of the symptom. These organizers are the framework that lend this process its originality. A clinical case illustrates how this psychotherapy, though brief, is able to remobilize a situation through retrieving the psychical historicity of the depressed episode. The authors’ clinical experience shows that this approach helps to create a space for lending an authentic psychoanalytic ear.