000			02064cam a2200205 4500500
005			20250112021257.0
041			_afre
042			_adc
100	1	0	_aPerottet, Jérémy _eauthor
700	1	0	_a Gondolf, Clémentine _eauthor
700	1	0	_a Grandhomme, Frédérique _eauthor
700	1	0	_a Creveuil, Christian _eauthor
700	1	0	_a Allouche, Stéphane _eauthor
245	0	0	_aFerritin as a predictive biomarker of severity in Covid-19
260			_c2022.
500			_a79
520			_aBackground: To prevent the crisis-level shortage of beds in hospitals and for more efficient support, it is necessary to early identify coronavirus disease-19 (Covid-19) patients at risk of developing a severe form of the disease. Objective: The aim of our study was to determine whether biological markers, including that of serum ferritin, could predict the severity of the Covid-19. Methods: One hundred and seventy-one patients with a positive diagnosis of Covid-19 by RT-PCR, who were admitted to Caen University Hospital, were included retrospectively. A serum ferritin measurement was performed for all patients. They were further classified either into a non-severe (n = 112) or a severe group (n = 59; those who were either hospitalized in the intensive care unit (ICU) and/or on mechanical ventilation, or who died). Results: Univariate analysis revealed a significant link between increased serum ferritin and CRP levels, obesity, CT scan lesions, pathological respiratory rate, decreased PaO2/FiO2 ratio, and the patient’s NEWS2 score. However, in a multivariate analysis, only CRP and obesity were associated with the severe form of Covid-19. Conclusion: While the pathological level of serum ferritin at admission is associated with the severe form of Covid-19, a combination of increased CRP levels and obesity would better predict the severity of the disease.
786	0		_nAnnales de Biologie Clinique | 80 | 4 | 2022-07-01 | p. 363-368 | 0003-3898
856	4	1	_uhttps://shs.cairn.info/journal-annales-de-biologie-clinique-2022-4-page-363?lang=en
999			_c135255 _d135255