000			02044cam a2200181 4500500
005			20250112021356.0
041			_afre
042			_adc
100	1	0	_aBarakett-Hamadé, Vanda _eauthor
700	1	0	_a Ghayad, Jean-Pierre _eauthor
700	1	0	_a Sleilaty, Ghassan _eauthor
245	0	0	_aEvaluation of equations for calculating LDL-cholesterol in patients with concomitant hypertriglyceridemia and low LDL-cholesterol: Is there a preferred equation?
260			_c2023.
500			_a35
520			_aIt is crucial to be able to reliably estimate low-density lipoprotein cholesterol (LDL-C) in patients with concomitant hypertriglyceridemia and low LDL-C. We retrospectively compared the performances of the Friedewald (LDL-F), Martin-Hopkins (LDL-MH), and Sampson (LDL-SA) equations against a direct homogeneous LDL-C assay (dLDL-C) on observations presenting mild hypertriglyceridemia (triglycerides between 1.69 and 3.9 mmol/L) and low LDL-C (< 2.58 mmol/L). Observations were stratified according to their LDL-C. Agreement of the equations with dLDL-C was assessed using intraclass correlation coefficients (ICCs) with an agreement cut-off of 0.9, and analysis of Bland–Altman plots. Independently of the LDL-C stratum evaluated, the three equations failed to meet the 0.9 ICC cut-off, although their agreement with dLDL-C improved as LDL-C increased. Analysis of Bland–Altman plots showed a downwards discordance of LDL-F with dLDL-C, and an upwards discordance of LDL-MH and LDL-SA with direct LDL-C. LDL-MH resulted in the fewest number of observations outside the Bland–Altman limits of agreement. While no equation can be deemed satisfactory enough to replace direct assays in patients with low LDL-C and concomitant hypertriglyceridemia, LDL-MH seems to perform better than the other equations in estimating LDL-C in these patients.
786	0		_nAnnales de Biologie Clinique | 81 | 1 | 2023-01-01 | p. 35-43 | 0003-3898
856	4	1	_uhttps://shs.cairn.info/journal-annales-de-biologie-clinique-2023-1-page-35?lang=en
999			_c135690 _d135690