| 000 | 02428cam a2200277zu 4500 | ||
|---|---|---|---|
| 001 | 88829637 | ||
| 003 | FRCYB88829637 | ||
| 005 | 20250107103722.0 | ||
| 006 | m o d | ||
| 007 | cr un | ||
| 008 | 250107s2015 fr | o|||||0|0|||eng d | ||
| 020 | _a9780124201941 | ||
| 035 | _aFRCYB88829637 | ||
| 040 |
_aFR-PaCSA _ben _c _erda |
||
| 100 | 1 | _aNeidhart, Michel | |
| 245 | 0 | 1 |
_aDNA Methylation and Complex Human Disease _c['Neidhart, Michel'] |
| 264 | 1 |
_bElsevier Science _c2015 |
|
| 300 | _a p. | ||
| 336 |
_btxt _2rdacontent |
||
| 337 |
_bc _2rdamdedia |
||
| 338 |
_bc _2rdacarrier |
||
| 650 | 0 | _a | |
| 700 | 0 | _aNeidhart, Michel | |
| 856 | 4 | 0 |
_2Cyberlibris _uhttps://international.scholarvox.com/netsen/book/88829637 _qtext/html _a |
| 520 | _aDNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunitySummarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging fieldDescribes wholly new concepts, including the linking of metabolic pathways with epigeneticsProvides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases | ||
| 999 |
_c14435 _d14435 |
||