000			02034cam a2200193 4500500
005			20251012013131.0
041			_afre
042			_adc
100	1	0	_aAdadi, Soukaina _eauthor
700	1	0	_a Drani, Meryem _eauthor
700	1	0	_a Ben-saghroune, Hayat _eauthor
700	1	0	_a Tlamçani, Zineb _eauthor
245	0	0	_aPrimary cutaneous aspergillosis with secondary invasive spread in an immunocompromised patient: A case report and literature review
260			_c2025.
500			_a49
520			_aAspergillosis is a rare fungal infection, and primary cutaneous manifestations are particularly uncommon. The majority of cases occur in immunocompromised patients. Case presentation We report the case of a 14-year-old adolescent with diabetes who developed primary cutaneous aspergillosis after a stay in the intensive care unit due to decompensation of her condition. During her hospitalization, an ulceronecrotic papule appeared on the tip of her nose. Mycological analysis of the skin sample isolated and identified Aspergillus fumigatus. The clinical course was marked by hematogenous dissemination of the fungus, with cerebral involvement. The patient died of multiple organ failure. Conclusion The clinical lesions of primary cutaneous aspergillosis are nonspecific and generally present as various types of lesions, such as macules, papules, nodules, and pustules. This diversity and lack of specificity can lead to misdiagnosis and delayed treatment. Hematogenous dissemination, especially to distant sites such as the brain, is a particularly serious concern and should be promptly investigated in immunocompromised patients. Direct microscopy, microbiological culture, and histopathological examination are essential for establishing the diagnosis of primary cutaneous aspergillosis.
786	0		_nCahiers Santé Médecine Thérapeutique | 34 | 2 | 2025-05-13 | p. 128-134 | 2780-8858
856	4	1	_uhttps://shs.cairn.info/journal-cahiers-sante-medecine-therapeutique-2025-2-page-128?lang=en&redirect-ssocas=7080
999			_c1528481 _d1528481