000			02130cam a2200157 4500500
005			20251012013252.0
041			_afre
042			_adc
100	1	0	_aLévy, Bernard _eauthor
245	0	0	_aMicrocirculation and hypertension: The cause and the victim
260			_c2025.
500			_a48
520			_aMicrocirculation is made up of arterioles, capillaries, and venules with a diameter of less than 20 μm; it plays a fundamental role in oxygen supply, nutrient exchange, and maintenance of tissue homeostasis. Hypertension and microcirculation form a vicious circle: Changes in microcirculation precede and contribute to the pathophysiology of hypertension. Hypertension, in turn, provokes and aggravates both structural and functional alterations in microcirculation, which contribute to systemic and target-organ-specific vascular damage. In hypertension, microvascular remodeling and rarefaction lead to a reduction in microvascular density, which in turn contributes to increased vascular resistance and insufficient perfusion of target organs (heart, brain, kidneys, retina). The pathophysiological mechanisms underlying microvascular dysfunction in hypertension include endothelial dysfunction and oxidative stress. These changes reduce the bioavailability of nitric oxide (NO), increase the production of reactive oxygen species (ROS), and promote inflammation and fibrosis of vascular walls and surrounding tissues. This review highlights the central role of microvascular dysfunction in hypertension-related complications and underscores the importance of early detection and therapeutic interventions. Strategies to optimize blood pressure control, improve endothelial function, and target oxidative stress and vascular remodeling are essential to mitigate the systemic consequences of hypertension-related microvascular damage and to reduce the burden of the resulting cardiovascular and renal diseases.
786	0		_nSang Thrombose Vaisseaux | Volume 37 | 1 | 2025-03-28 | p. 16-26 | 0999-7385
856	4	1	_uhttps://shs.cairn.info/journal-sang-thrombose-vaisseaux-2025-1-page-16?lang=en&redirect-ssocas=7080
999			_c1528986 _d1528986