000 01369cam a2200193 4500500
005 20251012013313.0
041 _afre
042 _adc
100 1 0 _aRedouté, Agathe
_eauthor
700 1 0 _a Kontopoulos, Nikolaos
_eauthor
700 1 0 _a Bertagnoli, Stéphane
_eauthor
700 1 0 _a Cordelier, Pierre
_eauthor
245 0 0 _aOncolytic viruses for the management of pancreatic cancer: Ongoing trials and therapeutic perspectives
260 _c2025.
500 _a6
520 _aDespite advances in research and clinical practice, pancreatic ductal adenocarcinoma remains a major public health challenge due to the lack of early detection and effective treatments. In this context, oncolytic viruses have emerged as a promising therapeutic alternative. These viruses selectively infect and lyse cancer cells after replication, while also having the potential to induce an antitumor immune response. This review explores the fundamental aspects of pancreatic cancer and its management, along with the principles of oncolytic virotherapy, highlighting clinically used viruses, before discussing the therapeutic potential of the SG33 myxoma virus strain in pancreatic cancer virotherapy.
786 0 _nVirologie | 29 | 4 | 2025-09-03 | p. 293-311 | 1267-8694
856 4 1 _uhttps://shs.cairn.info/journal-virologie-2025-4-page-293?lang=en&redirect-ssocas=7080
999 _c1529046
_d1529046