| 000 | 02285cam a2200277zu 4500 | ||
|---|---|---|---|
| 001 | 88973859 | ||
| 003 | FRCYB88973859 | ||
| 005 | 20251020123510.0 | ||
| 006 | m o d | ||
| 007 | cr un | ||
| 008 | 251020s2020 fr | o|||||0|0|||eng d | ||
| 020 | _a9781643680644 | ||
| 035 | _aFRCYB88973859 | ||
| 040 |
_aFR-PaCSA _ben _c _erda |
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| 100 | 1 | _aCastellani, Rudy J. | |
| 245 | 0 | 1 |
_aHandbook of Traumatic Brain Injury and Neurodegeneration _c['Castellani, Rudy J.'] |
| 264 | 1 |
_bSAGE Publications _c2020 |
|
| 300 | _a p. | ||
| 336 |
_btxt _2rdacontent |
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| 337 |
_bc _2rdamdedia |
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| 338 |
_bc _2rdacarrier |
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| 650 | 0 | _a | |
| 700 | 0 | _aCastellani, Rudy J. | |
| 856 | 4 | 0 |
_2Cyberlibris _uhttps://international.scholarvox.com/netsen/book/88973859 _qtext/html _a |
| 520 | _aHolbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field. | ||
| 999 |
_c1554492 _d1554492 |
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