000			01910cam a2200241 4500500
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041			_afre
042			_adc
100	1	0	_aGrunau, Ruth E. _eauthor
245	0	0	_aLong term effects of pain-related stress on neurodevelopment and pain perception of infants born very prematurely
260			_c2013.
500			_a4
520			_aEffets à long terme du stress lié à la douleur sur le neurodéveloppement et la perception de la douleur chez les enfants très grands prématurésWhile survival rates of infants born very prematurely increased greatly during the past three decades, neurodevelopmental outcomes have not improved. Problems in behavior, executive functions, visual perceptual abilities, learning, academic, and motor problems remain highly prevalent. Currently there is little understanding of the etiology and mechanisms that underlie these problems in this population, that are prevalent in former preterm children who escape major neurosensory or motor impairment. Given the extensive animal literature that has established causal foundations for the impact of early environmental stress on the developing organism, it is possible that exposure to prolonged and repetitive pain-related stress in infants born very preterm may potentially have long term effects contributing to altered neurobehavioral development in vulnerable infants. The focus of this review is evidence for long-term effects of early pain-related stress on brain development, neurodevelopment, programming of stress systems and later pain perception in infants born preterm.
690			_aPain
690			_aStress
690			_aCortisol
690			_aDevelopment
690			_aPreterm
690			_aBehavior
690			_aBrain
786	0		_nEnfance | o 1 | 1 | 2013-01-01 | p. 15-31 | 0013-7545
856	4	1	_uhttps://shs.cairn.info/journal-enfance2-2013-1-page-15?lang=en
999			_c161089 _d161089