| 000 | 03033cam a2200385 4500500 | ||
|---|---|---|---|
| 005 | 20260201051306.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aPolena, Helena _eauthor |
| 700 | 1 | 0 |
_aCallejon, Sylvie _eauthor |
| 700 | 1 | 0 |
_aSalvert, Marie _eauthor |
| 700 | 1 | 0 |
_aAbric, Elise _eauthor |
| 700 | 1 | 0 |
_aBuisson, Armonie _eauthor |
| 700 | 1 | 0 |
_aCadars, Benoît _eauthor |
| 700 | 1 | 0 |
_aGiraud, Félix _eauthor |
| 700 | 1 | 0 |
_aScalia, Julie _eauthor |
| 700 | 1 | 0 |
_aRemoue, Noëlle _eauthor |
| 700 | 1 | 0 |
_aArdiet, Nathalie _eauthor |
| 700 | 1 | 0 |
_aSayag, Michèle _eauthor |
| 700 | 1 | 0 |
_aTrompezinski, Sandra _eauthor |
| 700 | 1 | 0 |
_aPrestat-Marquis, Elodie _eauthor |
| 700 | 1 | 0 |
_aDréno, Brigitte _eauthor |
| 700 | 1 | 0 |
_aGraizeau, Christelle _eauthor |
| 245 | 0 | 0 | _aAn innovative ecobiological wound repair cream that restores the microbiome |
| 260 | _c2026. | ||
| 500 | _a10 | ||
| 520 | _aBackgroundSmall everyday wounds would benefit from optimal healing conditions, and the role of the microbiome in this process is being increasingly discussed. Objectives: To evaluate a wound repair cream (Cicabio Crème+, NAOS Ecobiology Company, Bioderma, France), assessing its effects on the skin microbiome and wound healing.Materials & MethodsThe impact on the microbiome was evaluated by monitoring restoration of diversity after disinfection. The efficacy of the repair complex was assessed ex vivo using a 3D wound-healing human skin model to analyse closure and protein expression. Short-term evaluation of adherence, gas permeability, wound protection, and hydration was assessed. In vivo efficacy was examined through two clinical studies: one on healing erosive areas and another after chemical peel.ResultsAfter disinfection, the cream accelerated restoration of microbiome diversity (+31%, p=0.001) without promoting pathogenic/commensal bacteria or altering the level of Staphylococcus epidermidis (p=0.193). In a 3D wound-healing model, the repair complex enhanced wound closure, promoting protein expression (Ki67, loricrin, CD44, collagen XVII, VII, III) and re-epithelialisation. The cream adhered to the skin, allowed gas exchange, and provided protection and hydration. In vivo, the cream reduced transepidermal water loss (day 4: p=0.016; day 7: p=0.014), erythema (day 7: p=0.023), and functional signs (day 4: p=0.032) of erosive wounds. Following chemical peels, the cream reduced inflammation (day 7: p=0.037), visible damage (day 7: p=0.029), and skin pH (day 1: pConclusionWe demonstrate, for the first time, protection of microbiome diversity, stimulation of wound closure, and preservation of skin pH using a wound repair cream. | ||
| 690 | _a3D skin model | ||
| 690 | _achemical peel | ||
| 690 | _aclinical evaluation | ||
| 690 | _amicrobiome | ||
| 690 | _awound healing | ||
| 786 | 0 | _nEuropean Journal of Dermatology | 35 | 6 | 2026-01-29 | p. 508-518 | 1167-1122 | |
| 856 | 4 | 1 | _uhttps://stm.cairn.info/journal-european-journal-of-dermatology-2025-6-page-508?lang=en&redirect-ssocas=7080 |
| 999 |
_c1639462 _d1639462 |
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