000			01636cam a2200253 4500500
005			20250112035638.0
041			_afre
042			_adc
100	1	0	_aBenetos, Athanase _eauthor
245	0	0	_aTelomere length: From cellular senescence to trajectories of human aging
260			_c2022.
500			_a64
520			_aThe last two decades have made it possible to understand the role of telomeres in the aging process and in longevity via their direct influence on replicative senescence and the capacity for tissue repair. Telomere length is primarily determined by genetic factors and secondarily by the influence of environmental factors during the first years of life. Short telomeres have a causal role in the development of age-related degenerative diseases and reduced longevity. Therefore, telomere length can be considered as a “biological capital” formed early in life, which plays an important role in the damage/repair balance at the cellular and tissue level and can thus influence the trajectory of aging. The integration of telomere length into a set of clinical, biological, and social data would make it possible to better individualize strategies for the prevention of age-related diseases, frailty, and loss of autonomy.
690			_acellular senescence
690			_aage-related diseases
690			_atelomeres
690			_aaging
690			_aAgeing
690			_aTelomeres
690			_aAge-related diseases
690			_aCellular senescence
786	0		_nHegel | - | 3 | 2022-11-08 | p. 269-280 | 2269-0530
856	4	1	_uhttps://shs.cairn.info/journal-hegel-2022-3-page-269?lang=en
999			_c173327 _d173327