| 000 | 02665cam a2200349 4500500 | ||
|---|---|---|---|
| 005 | 20260329022835.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aWang, Cui _eauthor |
| 700 | 1 | 0 |
_aLi, Yaoze _eauthor |
| 700 | 1 | 0 |
_aLin, Hao _eauthor |
| 700 | 1 | 0 |
_aZhu, Yulin _eauthor |
| 700 | 1 | 0 |
_aXu, Xiangdong _eauthor |
| 700 | 1 | 0 |
_aWu, PingPing _eauthor |
| 700 | 1 | 0 |
_aZhang, Yali _eauthor |
| 700 | 1 | 0 |
_aXu, Ting _eauthor |
| 700 | 1 | 0 |
_aRen, Jian _eauthor |
| 700 | 1 | 0 |
_aXu, Haibo _eauthor |
| 700 | 1 | 0 |
_aDong, Guoyu _eauthor |
| 700 | 1 | 0 |
_aXu, Yue _eauthor |
| 700 | 1 | 0 |
_aJiang, Huihui _eauthor |
| 700 | 1 | 0 |
_aZhao, Jiangman _eauthor |
| 700 | 1 | 0 |
_aZhai, Yufeng _eauthor |
| 700 | 1 | 0 |
_aPeng, Pei _eauthor |
| 700 | 1 | 0 |
_aZai, Guotian _eauthor |
| 245 | 0 | 0 | _aThe role of the small-dense LDL-C/large-buoyant LDL-C ratio as an independent risk factor in patients with type 2 diabetes mellitus and metabolic syndrome |
| 260 | _c2024. | ||
| 500 | _a18 | ||
| 520 | _aBackground Dyslipidemia plays a key role in metabolic syndrome (MS), intricately linked to type 2 diabetes mellitus (T2DM). Objective This study aimed to investigate the differences in low-density lipoprotein cholesterol (LDL-C) subfraction levels between T2DM and T2DM with MS, and identify the risk factors associated with the disease. Methods A total of 246 individuals diagnosed with T2DM (including 144 T2DM patients with MS) and 147 healthy subjects were recruited. All participants underwent a comprehensive clinical evaluation. Lipoprotein subfraction analysis was performed using the Lipoprint LDL system. Results Multivariate logistic regression analysis revealed that several lipid markers, including triglyceride (TG), LDL-C, large-buoyant LDL-C (lbLDL-C), small-dense LDL-C (sdLDL-C), LDLC2-5, and the sdLDL-C/lbLDL-C ratio, were identified as independent risk factors for T2DM. Additionally, TG, sdLDL-C, LDLC-4, LDLC-5, and the sdLDL-C/lbLDL-C ratio were found to be independent risk factors for T2DM with MS. Furthermore, the results of the receiver operating characteristic (ROC) curves demonstrated that sdLDL-C, LDLC-4, LDLC-3, and the sdLDL-C/lbLDL-C ratio exhibited excellent predictive performance for the risk of T2DM (AUC > 0.9). Conclusion The sdLDL-C/lbLDL-C ratio emerges as a shared independent risk factor for T2DM and MS complications. Furthermore, the sdLDL-C/lbLDL-C ratio, along with LDL-4 and LDL-3, exhibits noteworthy predictive capabilities for T2DM. | ||
| 786 | 0 | _nAnnales de Biologie Clinique | 82 | 2 | 2024-03-01 | p. 174-186 | 0003-3898 | |
| 856 | 4 | 1 | _uhttps://stm.cairn.info/journal-annales-de-biologie-clinique-2024-2-page-174?lang=en&redirect-ssocas=7080 |
| 999 |
_c1922998 _d1922997 |
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