000			02024cam a2200229 4500500
005			20250112063602.0
041			_afre
042			_adc
100	1	0	_aDominguez-Lafage, Clément _eauthor
700	1	0	_a Laganà, Marta _eauthor
700	1	0	_a Gesbert, Franck _eauthor
700	1	0	_a Marin-Esteban, Viviana _eauthor
700	1	0	_a Schlecht-Louf, Géraldine _eauthor
700	1	0	_a Bachelerie, Françoise _eauthor
700	1	0	_a Deback, Claire _eauthor
245	0	0	_aThe cutaneous virome: From virology to personalized medicine
260			_c2023.
500			_a73
520			_aThe cutaneous virome, defined as the collection of viruses detected in the skin, constitutes a significant part of the microbiota. A more recent discovery than bacterial flora, the existence of the cutaneous virome was unveiled through recent metagenomic studies. The virome of normal human skin is dominated by bacteriophages, Papillomaviridae—whose genomic diversity has proven extraordinary—and Polyomaviridae. Many viral genomes within this virome remain unidentified. The composition of the cutaneous virome has been shown to be strictly individual and relatively stable over time, reflecting its close adaptation to an individual’s genetics, lifestyle, and finely evolved mechanisms of immunological tolerance. Still underexplored, the cutaneous virome and its interactions with other microbiota microorganisms and with the host are attracting growing interest. Indeed, constitutional or acquired alterations in the homeostasis between the commensal virome and the skin, ranging from sub-clinical viral dysbiosis to severe transformation of keratinocytes or adnexal cells, have been observed. These recent findings are driving the search for innovative solutions to measure or even modulate its pathological expression, with promising prospects for personalized medicine.
786	0		_nVirologie | 27 | 6 | 2023-11-01 | p. 333-354 | 1267-8694
856	4	1	_uhttps://shs.cairn.info/journal-virologie-2023-6-page-333?lang=en
999			_c234396 _d234396