000			01934cam a2200313 4500500
005			20250112063751.0
041			_afre
042			_adc
100	1	0	_aGallois, Jean-Luc _eauthor
700	1	0	_a German-Retana, Sylvie _eauthor
245	0	0	_aeIF4E-mediated resistance to potyviruses in plants: From natural alleles to edited genes
260			_c2023.
500			_a7
520			_aResistance to viruses is an important aspect of plant breeding. Genetic resistance to viruses through loss of susceptibility has been selected in many crops. Among these resistances, translation initiation factors 4E (eIF4E) play a predominant role. In this article, we present a review of the research carried out on genes encoding translation initiation factors eIF4E, some of the most successful targets for obtaining resistance to potyviruses, since their characterization twenty years ago. With examples from different plant species (pepper, tomato, tobacco, and Arabidopsis), we present the foundations of this type of resistance and its characteristics, highlighting the role of gene redundancy among 4E factors, their virus specificity, and the necessary trade-off in plants between resistance and development. Finally, we show how the new genome-editing techniques could be used in plant breeding to develop eIF4E-based resistances in crops, by mimicking the functional alleles that have been selected during evolution in many crops.
690			_asusceptibility factors
690			_aPotyvirus
690			_aeIF4E
690			_aplants
690			_agenome editing
690			_anatural resistances
690			_asusceptibility factors
690			_aplants
690			_aPotyvirus
690			_aeIF4E
690			_agenome edition
690			_anatural resistances
786	0		_nVirologie | 27 | 4 | 2023-07-01 | p. 225-337 | 1267-8694
856	4	1	_uhttps://shs.cairn.info/journal-virologie-2023-4-page-225?lang=en
999			_c235231 _d235231