000			01666cam a2200205 4500500
005			20250112063758.0
041			_afre
042			_adc
100	1	0	_aEspinosa Ortiz, Armando _eauthor
700	1	0	_a Modica, Alessandro _eauthor
700	1	0	_a Fromentin, Rémi _eauthor
700	1	0	_a Chomont, Nicolas _eauthor
700	1	0	_a Chomont, Nicolas _eauthor
245	0	0	_aImmunological mechanisms involved in the persistence of HIV reservoirs
260			_c2022.
500			_a46
520			_aAntiretroviral therapy (ART) controls viral replication and has dramatically improved the quality of life and life expectancy of people living with HIV (PLHIV). However, almost forty years after the discovery of HIV, there is still no cure; even after years of effective ART, the virus persists in cells, primarily memory CD4 T cells. These cells are a perennial source of infectious viruses, which require people living with HIV to continue ART for life. Research on HIV reservoirs over the past twenty-five years has provided insight into how some infected cells persist for decades without being cleared by ART or by immune responses. HIV “hides” in cells with extended lifespans, which have the capacity to proliferate through diverse mechanisms and which preferentially express several receptors that allow them to remain invisible to the immune system. A better understanding of these mechanisms of persistence is a necessary pre-requisite for the development of therapeutic strategies aimed at eradicating HIV.
786	0		_nVirologie | 26 | 1 | 2022-01-01 | p. 9-22 | 1267-8694
856	4	1	_uhttps://shs.cairn.info/journal-virologie-2022-1-page-9?lang=en
999			_c235268 _d235268