| 000 | 02734cam a2200277 4500500 | ||
|---|---|---|---|
| 005 | 20250112063927.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aTaha, Sara Ibrahim _eauthor |
| 700 | 1 | 0 |
_a Samaan, Sara Farid _eauthor |
| 700 | 1 | 0 |
_a Ibrahim, Rehab Ali _eauthor |
| 700 | 1 | 0 |
_a El-Sehsah, Eman Mousa _eauthor |
| 700 | 1 | 0 |
_a Youssef, Mariam Karam _eauthor |
| 245 | 0 | 0 | _aPost-COVID-19 arthritis: is it hyperinflammation or autoimmunity? |
| 260 | _c2021. | ||
| 500 | _a63 | ||
| 520 | _aBackground: Various musculoskeletal and autoimmune manifestations have been described in patients with coronavirus disease 2019 (COVID-19). Objectives: This study aims to investigate the prevalence and etiology of arthritis in post-COVID Egyptian patients. Methods: We included 100 post-COVID Egyptian patients who recovered 6 months ago and assessed several inflammatory and autoimmune markers. Results: The prevalence of post-COVID arthritis was 37%. Ankle, knee, and wrist were the most commonly affected joints. Old age (P = 0.010), smoking (P = 0.001), and arthralgia (P = 0.049) were all linked with post-COVID arthritis. Levels of pretreatment (baseline) interleukin (IL)-6 (46.41 ± 3.67 vs. 24.03 ± 2.46; P = 0.001), as well as 6-month post-COVID C-reactive protein (CRP; 98.49 ± 67.55 vs. 54.32 ± 65.73; P = 0.002), and erythrocyte sedimentation rate (ESR; 109.08 ± 174.91 vs. 58.35 ± 37.87; P = 0.029) were significantly higher in patients with arthritis compared to those without. On the other hand, complement C3 (P = 0.558) and C4 (P = 0.192), anti-nuclear antibodies (P = 0.709), and anti-cyclic citrullinated peptides (anti-CCP; P = 0.855) did not show significant differences. Only pretreatment IL-6 level was the significant single predictor of post-COVID arthritis with an odds ratio (95% confidence interval) of 3.988 (1.460–10.892) and a P-value of 0.007. Conclusion: The strong association observed with inflammatory markers (ESR and CRP) and the insignificant association with serologic markers of autoimmunity (ANA and anti-CCP) in our study support the notion that the underlying mechanism of post-COVID-19 arthritis is primarily due to the hyperinflammatory process associated with COVID-19 infection, and not the result of an autoimmune reaction. IL-6 levels before therapy can predict post-COVID arthritis allowing for early management. | ||
| 690 | _aArthritis | ||
| 690 | _aMusculoskeletal | ||
| 690 | _aRheumatology | ||
| 690 | _aAutoimmunity | ||
| 690 | _aPost-COVID | ||
| 690 | _aHyperinflammation | ||
| 786 | 0 | _nEuropean Cytokine Network | Volume 32 | 4 | 2021-12-01 | p. 83-88 | 1148-5493 | |
| 856 | 4 | 1 | _uhttps://shs.cairn.info/revue-european-cytokine-network-2021-4-page-83?lang=en |
| 999 |
_c235847 _d235847 |
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