| 000 | 02386cam a2200253 4500500 | ||
|---|---|---|---|
| 005 | 20250121154410.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aDezoteux, Frédéric _eauthor |
| 700 | 1 | 0 |
_a Astrid, Bellissen _eauthor |
| 700 | 1 | 0 |
_a Chuffard, Marie _eauthor |
| 700 | 1 | 0 |
_a Drumez, Elodie _eauthor |
| 700 | 1 | 0 |
_a Azib, Selma _eauthor |
| 700 | 1 | 0 |
_a Staumont-Sallé, Delphine _eauthor |
| 245 | 0 | 0 | _aAtopic dermatitis in elderly adults |
| 260 | _c2019. | ||
| 500 | _a43 | ||
| 520 | _aBackground: Atopic dermatitis (AD) in adults over 45 years of age (AD≥45) has been poorly studied. Objectives: To determine whether the AD phenotype varies according to the pattern of AD onset in AD≥45 patients and whether response to cyclosporine A (CsA) is influenced by age. Materials and Methods: This monocentric retrospective study was performed in a French university department of dermatology. We included 409 AD<45 patients (111 treated with CsA) and 124 AD≥45 patients (26 treated with CsA). Among AD≥45 patients, 20% were categorised into Subgroup 1 (persistence of AD since childhood), 52% into Subgroup 2 (recurrence of AD with a history of classic childhood AD), and 28% into Subgroup 3 (adult-onset AD). Results: Gender, associated atopic comorbidities, a family history of atopy, and AD severity were similar regarding the different patterns of AD onset in AD≥45 patients. Skin lesions predominated on the face and neck in AD≥45 patients with AD since childhood (30% in Subgroups 1 and 2) compared to those with adult-onset AD (14% in Subgroup 3). The efficacy of CsA was similar between groups AD≥45 and AD<45, but 28% of AD≥45 patients versus 20% of AD<45 patients had increased serum creatinine levels under CsA. Conclusion: No significant association seems to exist between the onset of AD and demographic or clinical characteristics in AD≥45 patients (except that head and neck involvement is rarer in adult-onset AD). Patient age does not influence response to CsA, but this drug appears to be less well tolerated in older patients. | ||
| 690 | _aadults | ||
| 690 | _aatopic dermatitis | ||
| 690 | _acyclosporine A | ||
| 786 | 0 | _nEuropean Journal of Dermatology | 29 | 4 | 2019-07-01 | p. 371-374 | 1167-1122 | |
| 856 | 4 | 1 | _uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2019-4-page-371?lang=en&redirect-ssocas=7080 |
| 999 |
_c602148 _d602148 |
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