| 000 | 02622cam a2200313 4500500 | ||
|---|---|---|---|
| 005 | 20250121154508.0 | ||
| 041 | _afre | ||
| 042 | _adc | ||
| 100 | 1 | 0 |
_aYang, Fanping _eauthor |
| 700 | 1 | 0 |
_a Chen, Zihua _eauthor |
| 700 | 1 | 0 |
_a Chen, Sheng-an _eauthor |
| 700 | 1 | 0 |
_a Zhu, Qinyuan _eauthor |
| 700 | 1 | 0 |
_a Wang, Lanting _eauthor |
| 700 | 1 | 0 |
_a Xiong, Hao _eauthor |
| 700 | 1 | 0 |
_a Fu, Haijun _eauthor |
| 700 | 1 | 0 |
_a Luo, Xiaoqun _eauthor |
| 245 | 0 | 0 | _aClinical profile of cutaneous adverse drug reactions: a retrospective study of 1883 hospitalized patients from 2007 to 2016 in Shanghai, China |
| 260 | _c2020. | ||
| 500 | _a44 | ||
| 520 | _aBackground: Cutaneous adverse drug reactions (CADRs) are drug-induced skin reactions with or without systemic involvement, ranging from mild maculopapular exanthema (MPE) to life-threatening severe CADRs (S-CADRs). Due to their unpredictability and severity, early recognition of suspected causative drugs is highly recommended. However, the profile of CADRs remains unknown in China. Objectives: To assess the clinical profile, predominant causative drugs, and cost associated with CADRs in Shanghai, China. Materials and Methods: Clinical records of inpatients admitted with a diagnosis of CADRs to the dermatology ward of Huashan Hospital from January 2007 to December 2016 were retrospectively studied. Results: A total of 1,883 patients (1,231 female and 652 male), admitted with a diagnosis of CADR, were investigated. S-CADRs made up 21.99% of all cases ( n=414), and urticaria (27.19%) was the most frequent reaction. Of the patients, 53.43% suffered from multiple drug-induced drug eruptions and the rest (45.83%) from single drug-induced drug eruptions. Overall, antimicrobials (28.85%) was the main drug group involved, and for S-CADRs, this was antiepileptic drugs (36.15%). The total cost for CADRs was RMB23,718,788.83 ($3,588,319.04). Both age and sex were related to admission cost ( p=0.005 and p=7.84E-8, respectively). Antimicrobials were the most common treatment causing CADRs. Conclusion: The management of CADRs requires considerable medical cost. CADRs are not only a health problem but also a significant financial burden for affected individuals. | ||
| 690 | _acosts | ||
| 690 | _amedicine | ||
| 690 | _aChinese traditional | ||
| 690 | _acausative drugs | ||
| 690 | _aanti-bacterial agents | ||
| 690 | _adrug eruptions | ||
| 786 | 0 | _nEuropean Journal of Dermatology | 30 | 1 | 2020-01-01 | p. 24-31 | 1167-1122 | |
| 856 | 4 | 1 | _uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2020-1-page-24?lang=en&redirect-ssocas=7080 |
| 999 |
_c602448 _d602448 |
||