000			02110cam a2200253 4500500
005			20250121154511.0
041			_afre
042			_adc
100	1	0	_aHur, Min Seok _eauthor
700	1	0	_a Hong, Ji Youn _eauthor
700	1	0	_a Hong, Joo Ran _eauthor
700	1	0	_a Lee, Yang Won _eauthor
700	1	0	_a Choe, Yong Beom _eauthor
700	1	0	_a Ahn, Kyu Joong _eauthor
245	0	0	_aClinical characteristics of psoriatic patients with latent tuberculosis infection
260			_c2020.
500			_a74
520			_aBackground: Psoriasis is an immune-mediated inflammatory disease in which imbalance of the immunological response may be associated with disease severity and comorbidities. Latent tuberculosis infection (LTBI) is a growing concern for treatment of psoriasis, as the use of biologics has recently increased. Objectives: To investigate the clinical and immunological influence of LTBI on the features of psoriasis. Materials and Methods: We conducted a retrospective analysis of 300 patients with psoriasis using clinical information, including severity, comorbidities, and presence of LTBI. Serum cytokine levels were measured for immunological analysis. Results: The prevalence of psoriatic arthritis ( p = 0.001) and nail psoriasis ( p = 0.014) in patients with LTBI was significantly higher than in those without LTBI, although other data including the Psoriasis Area Severity Index showed no association. The serum levels of interleukin (IL)-6, IL-8, and IL-23A in the LTBI-positive group were higher than those in the LTBI-negative group ( p = 0.014, p = 0.025, and p = 0.004, respectively). Conclusion: LTBI may be a risk factor for the development of psoriatic arthritis during chronic inflammatory conditions induced by tuberculosis infection.
690			_apsoriatic arthritis
690			_alatent tuberculosis
690			_apsoriasis
786	0		_nEuropean Journal of Dermatology | 30 | 2 | 2020-03-01 | p. 127-132 | 1167-1122
856	4	1	_uhttps://shs.cairn.info/revue-european-journal-of-dermatology-2020-2-page-127?lang=en&redirect-ssocas=7080
999			_c602478 _d602478